An discussion on the relationship between information theory, biology and thermodynamics, centered on transcription factor binding sites and cast in the light of evolutionary theory.
Printable version (PDF; has lost italics and some other formatting).
A gently paced introduction to the field of information theory and its application to the modeling of transcription factor binding motifs.
A short description of the concept of sequence logo and its roots in information theory.
A discussion on (and rebuttal of) the “theoretical” notion that transcription factor binding motifs can carry “negative” information.
An analysis of the efficiency of weighted vs. non-weighted methods for transcription factor-binding site search.